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On 14 March 2011, the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), hosted by the European Commission’s Joint Research Centre (JRC), issued a recommendation concerning three in vitro test methods for assessment of the carcinogenic potential of chemical substances. In conjunction with other available data, the test methods can be used to decide whether it is necessary to carry out animal testing for carcinogenicity (cancer bioassay) in the context of EU legislation.

They therefore have the potential to reduce and replace testing on animals. The three in vitro cell transformation assays (CTA), based on the use of cells originated from mouse and hamsters, model several stages of the cancer development process. The recommendation concludes that these methods can partially replace the currently used rodent carcinogenicity OECD Test Guidelines 451 and 453 which can lead to a reduction of laboratory animals and the time for toxicity testing needed.

EURL ECVAM’s study of the three test methods was peer reviewed by the EURL’s Scientific Advisory Committee (ESAC), and the recommendation underwent public consultation. The EURL ECVAM forwarded the results to the OECD for potential inclusion into the OECD Test Guidelines and subsequent international regulatory acceptance.

More information:
http://ihcp.jrc.ec.europa.eu/

Objetivo/s del curso:

Presentación de una visión integradora desde diversos sectores (Científico, Industria, Administración, etc) y con una perspectiva multidisciplinar sobre las Iniciativas y retos en relación con sustancias químicas de uso y consumo: Reglamento REACH, Convenio de Estocolmo sobre COP y nanomateriales.

Profesores:

Juan José Vaquero, Bernardo Herradón, Eduardo de la Peña, Mª José González Muñoz, Ana de la Torre Reoyo, Matilde Carballo, Covadonga Caballo, Esther Martín, José Manuel Pérez, Mª Dolores Hernando, Ana Mª García, Mª Eugenia Anta, Ruth Jiménez, Guillermo Repetto, Carmen José Mateos Vega, Araceli Pillco, Juan Carlos Flores Serrano, José Mª Navas, Mercedes Torre, Ernesto de Jesús, Óscar Herrero de Felipe.

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La EPAA (Asociacion Europea sobre estrategias alternativas a la experimentacion animal) convoca, por segunda vez, un premio cientifico que pretende respaldar la optimizacion y aceptacion regulatoria de metodos alternativos a la experimentacion con animales (3Rs: reducir, refinar y reemplazar) . Este premio ofrece a los jovenes investigadores la oportunidad de cooperar con cientificos de nombrada experiencia en varios sectores de la industria y con la Comision Europea.

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